Computational protocol: Intra-individual variability of mycophenolic acid concentration according to renal function in liver transplant recipients receiving mycophenolate monotherapy

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Protocol publication

[…] To avoid bias from intra-individual variations in serum creatinine level, the mean values of consecutive three measurements (usually during 6 months) were used to classify the patients based on renal function. The serial 12-hour MPA levels during the latest 12 months were obtained. Considering that the patients usually visited the outpatient clinic every 2-3 months and MPA TDM was performed at every visit, the MPA TDM sample number per patient was ≥5. MPA TDM-associated values were reported as mean with standard deviation (SD) and coefficient of variation (CV); wherein the CV is the ratio of the SD in trough blood concentration to the mean trough concentration (expressed as percentage) as follows: “CV=SD/Mean×100%”.Numerical variables were presented as means with SD and ranges. Continuous variables were compared with the Student t-test. A p-value <0.05 was considered to indicate a statistically significant difference. Statistical analyses were performed using SPSS (version 22; IBM, New York, NY) and Statistica (version 6.0; StatSoft, Tulsa, OK) software. […]

Pipeline specifications

Software tools SPSS, Statistica
Application Miscellaneous
Organisms Homo sapiens
Chemicals Mycophenolic Acid, 3-Mercaptopropionic Acid