Computational protocol: A common haplotype within the PON1 promoter region is associated with sporadic ALS

Similar protocols

Protocol publication

[…] Allelic association testing and inferring individual haplotypes was performed using the software application PLINK v0.99p (http://pngu.mgh.harvard.edu/˜purcell/plink/). Haploview v4.0 (http://www.broad.mit.edu/mpg/haploview/) was used to determine the linkage disequilibrium in the PON region. Bonferroni multiple test correction was applied by multiplying PLINK-derived p-values by the number of SNPs or haplotypes assayed. […]

Pipeline specifications

Software tools PLINK, Haploview
Application GWAS
Diseases Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases