Transcriptomics Analysis and Hormonal Changes of Male and Female Rats Treated Chronically with a Low Dose of Acrylamide in their Drinking Water

A transcriptomics approach (microarrays and bioinformatics) was used to investigate changes in gene expression and the association with physiological responses (changes in plasma hormone levels) in rats treated with acrylamide (AA) from gestational day 6 to post natal day 35. We hypothesized that 3 mg AA/Kg bw/day exposure would produce changes in plasma hormone levels associated with key genes and pathways involved with molecular actions of AA.