Computational protocol: Allelic Polymorphism Determines Surface Expression or Intracellular Retention of the Human NK Cell Receptor KIR2DL5A (CD158f)

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Protocol publication

[…] We based on the KIR2DL1 X-ray structure () (PDB accession code: 1NKR) to predict the structures of the D2 Ig-like domains of KIR2DL5A*001 and *005, using the SWISS-MODEL automated protein structure homology-modeling system (), accessible via the ExPASy web server. Quality of each model was assessed with the QMEAN Z-score (), which describes the likelihood that a model quality is comparable to high-resolution experimental structures. Structures were visualized and edited using the PyMOL Molecular Graphics System (version 1.7.4, Schrödinger, LLC). […]

Pipeline specifications

Software tools SWISS-MODEL, QMEAN, PyMOL
Databases ExPASy
Application Protein structure analysis
Organisms Homo sapiens
Chemicals Amino Acids, Aspartic Acid, Glycine