Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 22
Release date: Sep 5 2013
Last update date: May 12 2015
Access: Public
Diseases: Down Syndrome, Nervous System Malformations
Dataset link Analysis of the Cerebral Cortex and Hippocampus Transcriptome Reveals Unique Molecular Changes in the Ts1Cje Mouse Model of Down Syndrome

Experimental Protocol


We analyzed the cerebral cortex and hippocampus whole transcriptome from 8-10 weeks old Ts1Cje (n=6) and wild-type (n=5) using Affymetrix mouse gene 1.0 ST array. Data were normalized and analyzed to identify and accurately map genes that are significantly differentially expressed. Functional analyses were performed using GSEA and DAVID to better characterize cellular processes and pathways that are consistently affected in both brain regions.

Repositories


GEO

GSE49635

ArrayExpress

E-GEOD-49635

BioProject

PRJNA214547

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Contact


Heather Wick
Heather C Wick