|Application:||Gene expression microarray analysis|
|Number of samples:||22|
|Release date:||Sep 5 2013|
|Last update date:||May 12 2015|
|Diseases:||Down Syndrome, Nervous System Malformations|
|Dataset link||Analysis of the Cerebral Cortex and Hippocampus Transcriptome Reveals Unique Molecular Changes in the Ts1Cje Mouse Model of Down Syndrome|
We analyzed the cerebral cortex and hippocampus whole transcriptome from 8-10 weeks old Ts1Cje (n=6) and wild-type (n=5) using Affymetrix mouse gene 1.0 ST array. Data were normalized and analyzed to identify and accurately map genes that are significantly differentially expressed. Functional analyses were performed using GSEA and DAVID to better characterize cellular processes and pathways that are consistently affected in both brain regions.
Heather C Wick