Computational protocol: Chemically Induced Oncogenesis in the Peripheral Nervous System Is Suppressed in Congenic BDIX.BDIV-Mss1 and -Mss7 Rats

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Protocol publication

[…] We analyzed times until visible signs of tumor development occurred to describe differences in latency times in different strains. As animals died or had to be killed within a few days after diagnosis, latency and survival time are almost identical. Rats lost as the result of nonmalignant disease or malignancies different from MPNST were considered “censored events.” Data are presented as Kaplan-Meier survival curves and on this basis median survival times and MPNST incidences on day 200 with 95% confidence intervals, respectively, were calculated. Strain- and sex-specific curves were compared with log rank tests. P < 0.05 was considered significant. Statistical evaluations were carried out with SigmaPlot 11 and SPSS V21. […]

Pipeline specifications

Software tools SigmaPlot, SPSS
Application Miscellaneous
Organisms Rattus norvegicus, Homo sapiens
Diseases Neurilemmoma, Sarcoma, Neurofibromatoses, Chemically-Induced Disorders
Chemicals Ethylnitrosourea