Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 8
Release date: Dec 17 2015
Last update date: Nov 9 2017
Access: Public
Diseases: Gastritis, Gastritis, Atrophic, Inflammation, Metaplasia, Neoplasms, Stomach Diseases, Stomach Neoplasms, Retinal Dysplasia
Dataset link The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in mice (mouse)

Experimental Protocol


A cohort of individuals having at least Multifocal Atrophic Gastritis (MAG) was follwed for 6 six years to study the evolution of the gastric lesions over time. The gene CD44 was found to be significantly different between the baseline and follow-up samples of individuals with progression to more advanced gastric lesion. Mouse models of H. pylori infection in wild type and CD44-/- mice showed that the KO mice had reduced levels of gastric itestinal metaplasia than their wild type counterparts after infection. The lesions were associated with differential immune responses and infiltration of GR1 positive cells

Repositories


GEO

GSE69145

BioProject

PRJNA284639

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Contact


Jovanny Zabaleta