Dataset features

Specifications


Application: Gene expression microarray analysis, miRNA array analysis
Number of samples: 38
Release date: Apr 25 2012
Last update date: Apr 25 2012
Access: Public
Diseases: Neoplasms, Rectal Neoplasms, Colorectal Neoplasms
Dataset link A specific miRNA signature correlates with complete pathological response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer

Experimental Protocol


Experiments were performed on purified RNA from preoperatory biopsies of 38 patients with histological diagnosis of rectal adenocarcinoma invading through the intestinal wall and/or with pelvic lymph node involvement as evaluated by endorectal ultrasonography (uT3-T4 and/or uN+). Patients were treated with neoadjuvant chemo-radiotherapy (capecitabine + oxaliplatin in combination with 45 Gy of pelvic conformal radiotherapy). Patients have been divided in the following two groups: group A those who had obtained a pathologic complete response – TRG 1, including the patient without detectable disease who refused surgery, group B any pathologic response other than complete.

Repositories


GEO

GSE29298

ArrayExpress

E-GEOD-29298

BioProject

PRJNA138625

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Contact


Francesca Falcetta