|Application:||Gene expression microarray analysis, miRNA array analysis|
|Number of samples:||38|
|Release date:||Apr 25 2012|
|Last update date:||Apr 25 2012|
|Diseases:||Neoplasms, Rectal Neoplasms, Colorectal Neoplasms|
|Dataset link||A specific miRNA signature correlates with complete pathological response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer|
Experiments were performed on purified RNA from preoperatory biopsies of 38 patients with histological diagnosis of rectal adenocarcinoma invading through the intestinal wall and/or with pelvic lymph node involvement as evaluated by endorectal ultrasonography (uT3-T4 and/or uN+). Patients were treated with neoadjuvant chemo-radiotherapy (capecitabine + oxaliplatin in combination with 45 Gy of pelvic conformal radiotherapy). Patients have been divided in the following two groups: group A those who had obtained a pathologic complete response â TRG 1, including the patient without detectable disease who refused surgery, group B any pathologic response other than complete.