A general repository for chromatin interaction data. Records in 4DGenome are compiled through comprehensive literature curation of experimentally-derived and computationally-predicted interactions. The current release contains 4,433,071 experimentally-derived and 3,605,176 computationally-predicted interactions in 5 organisms. Experimental data cover both high throughput datasets and individiual focused studies. All interaction data are freely available in a standardized file format. Records can be queried by genomic regions, gene names, organism, and detection technology.