Computational protocol: The Motor Recovery Related with Brain Lesion in Patients with Intracranial Hemorrhage

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Protocol publication

[…] Lesion size was calculated using the Picture Achieved Communication System (PACS, Marotech, Korea), and the absolute lesion size (cm3) was determined by multiplying the sum of all lesion areas in each plane by the slice thickness.Lesion locations were subject to mutual analysis using MRIcron. The origin of the image (0, 0, 0 mm coordinates) was reoriented such that it was located close to the anterior commissure. Volume of interest (VOI) images of each patient were traced using MRIcron (http://www.mricro.com/mricron/). The VOI images were transformed to the left hemisphere. The tracings were coregistered to the Montreal Neurological Institute brain template []. To analyze the mutual lesion maps, the following process was used. First, the T1 images were roughly aligned to standard space. This approximately locates the anterior commissure, which will aid in subsequent normalization. Then, the T2 scan was coregistered to the space in the T1 scan. The T2 image is moved and rotated until closely aligned to the T1 image. Third, the T1 image was aligned to stereotaxic space using unified segmentation and normalization in SPM8. To identify relevant anatomic structures implicated in the analyses, Talairach Daemon (http://www.talairach.org/) was used []. […]

Pipeline specifications

Software tools MRIcron, SPM
Application Magnetic resonance imaging
Organisms Homo sapiens
Diseases Brain Diseases, Stroke