Dataset features

Specifications


Application: ChIP-on-chip analysis
Number of samples: 19
Release date: Aug 30 2014
Last update date: Nov 12 2014
Access: Public
Taxon: Mus musculus
Computational protocol: RUM, DESeq
Dataset link Paternal poly(ADP-ribose) metabolism modulates retention of inheritable sperm histones and early embryonic gene expression [PJ34_sperm_MNaseb]

Experimental Protocol


Mnase sensitivity of sperm DNA, indicating nucleosomal, not protamine, packaging was altered in mice by manipulating poly(ADP-ribose) metabolism in adult males using a specific PARP inhibitor for 6 weeks. Abnormal sperm nucleosomal organization of males analyzed by these tiling arrays was compared with differential gene expression in 2 cell embryos fathered by these males analyzed by separate gene expression arrays and RNA sequencing.

Repositories


GEO

GSE56282

ArrayExpress

E-GEOD-56282

BioProject

PRJNA242838

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Contact


Ralph Meyer
Ralph G Meyer

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