|Application:||Gene expression microarray analysis|
|Number of samples:||10|
|Release date:||Nov 15 2014|
|Last update date:||May 12 2015|
|Diseases:||Nervous System Malformations|
|Dataset link||Analysis of the Fetal and Neonatal Transcriptomic and Neurocognitive Phenotype in the Ts1Cje Mouse Model of Down syndrome|
We analyzed the forebrain whole transcriptome from embryonic day 15.5 (E15.5) Ts1Cje (n=5) and wild-type (n=5) using Affymetrix mouse gene 1.0 ST array. Data were normalized and analyzed to identify and accurately map genes that are significantly differentially expressed. Functional analyses were performed using GSEA and DAVID and DFLAT to better characterize cellular processes and pathways that are consistently affected in both brain regions. In separate experiments, the Fox scale, ultrasonic vocalization and homing tests were used to investigate postnatal behavioral deficits in Ts1Cje pups (n=29) versus WT littermates (n=64) at days 3 to 21.
Heather C Wick