|Application:||Gene expression microarray analysis|
|Number of samples:||6|
|Release date:||Feb 28 2012|
|Last update date:||Aug 23 2018|
|Diseases:||Hamartoma Syndrome, Multiple, Prostatic Neoplasms|
|Dataset link||Pten loss and RAS/MAPK activation cooperate to promote EMT and prostate cancer metastasis initiated from stem/progenitor cells|
Murine mutants with prostate specific loss of Pten and K-ras activation (K-rasG12D) under regulation of the probasin promoter developed high grade, invasive prostate cancer. RNA was extracted from dissected prostate lobes from individual mutants with pathology thought to closely mimic human disease. Prostate tissue was subject to RNA extraction and hybridization on Affymetrix cDNA microarrays.
Linh My Tran