Computational protocol: Low copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis

Similar protocols

Protocol publication

[…] The distributions of FCGR3B CN between patients and controls and between patients with and without RF, anti-CCP and radiographic erosions were compared using the maximum likelihood chi-square test with two degrees of freedom. Logistic regression analysis was used to calculate odds ratios (ORs) for low CN (< 2) and high CN (> 2), both relative to the normal diploid 2CN for RA patients compared with controls. P < 0.05 was considered statistically significant. Analysis was performed using Statistica version 6 (Statsoft, Tulsa, OK, USA).A random-effects meta-analysis of previously published studies examining the relationship between low CN of FCGR3B and RA was performed using the R metafor library [,] and the restricted maximum-likelihood method. […]

Pipeline specifications

Software tools Statistica, metafor
Applications Miscellaneous, Gene expression microarray analysis
Organisms Homo sapiens
Diseases Arthritis, Rheumatoid, Autoimmune Diseases