Computational protocol: Examination of soluble integrin resistant mutants of foot-and-mouth disease virus

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Protocol publication

[…] Amino acid sequences of SIRs were used to construct homology models of the G-H loop and capsid protomers using the Geno3D algorithm []. Ten most likely structures were generated using a solved structure as a template. Two X-ray crystal structures for the major immunogenic site of FMDV designated 1FOD [] and 1ZBE [] in the Protein Data Bank (PDB) were selected as templates. Hypothetical structures were examined using DeepView [,], and a consensus structure for each sequence was selected. […]

Pipeline specifications

Software tools GENO3D, Swiss-PdbViewer
Application Protein structure analysis
Diseases Foot-and-Mouth Disease, Mucopolysaccharidosis III