Dataset features

Specifications


Application: RNA-seq analysis
Number of samples: 79
Release date: Aug 17 2017
Last update date: Nov 21 2018
Access: Public
Genes: SOX2, TBX1, TBX6
Taxon: Homo sapiens
Dataset link Antagonistic activities of Sox2 and Brachyury control the fate choice of neuro-mesodermal progenitors

Experimental Protocol


Bulk transcriptomes (RNA-Seq) and chromatin accessibility (ATAC-Seq) from T/Sox2 expressing subpopulations isolated during trunk development from wildtype and T knock-out mouse embryos. Data is supplemented by Fluidigm single-cell RNA-Seq for T/Sox2 co-expressing cells from wildtype embryos and a bulk RNA-Seq comparison of wildtype and Tbx6 knock-out mouse embryos. ChIP-Seq for T, Sox2, Tbx6 and beta-catenin has been performed with chromatin from in vitro differentiated neuromesodermal progenitors and presomitic mesoderm.

Repositories


GEO

GSE93524

ENA

SRP096588

BioProject

PRJNA360989

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