|Number of samples:||40|
|Release date:||Aug 24 2016|
|Last update date:||Oct 24 2018|
|Diseases:||Alzheimer Disease, Pregnancy, Prolonged, Neoplasms, Second Primary, Hematologic Neoplasms|
|Genes:||IL15, MTOR, IL2, STAT5A|
|Dataset link||IL-15 activates mTOR and primes stress-activated gene-expression leading to prolonged anti-tumor capacity of NK cells|
Freshly isolated NK cells from 6 donors were activated with IL-2 or IL-15 for 48 hours, followed by cytokine withdrawal for 24 hours, resulting in four RNA samples per donor. From each sample, both the cytosolic as well as the polysomal fraction were collected. Donor 3 contains activation and post withdrawal data from two different donors due to poor RNA-quality obtained for some samples which did not allow for processing of the complete set of 6 donors (resulting in a total of 40 samples).