Computational protocol: Establishment of a risk scoring system for predicting locoregional recurrence in T1 to T2 node-negative breast cancer patients treated with mastectomy

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Protocol publication

[…] The observation endpoints included overall survival (OS) (defined as the survival time from surgery to death from any cause), locoregional recurrence-free survival (LRFS) (defined as the time from surgery to pathologically confirmed LRR), and disease-free survival (DFS) (defined as the time from surgery to recurrence, distant metastasis, or death). LRR occurring simultaneously with distant metastasis was considered as an LRR event, but patients who had distant metastasis before LRR were excluded.The prognostic factors were screened by Kaplan–Meier univariate analysis, and the survival curves were compared using log-rank test. In particular, the cutoff point of tumor size affecting survival was determined by Cutoff Finder application.[] Total risk scores were initially derived using Cox proportional hazards model according to beta regression coefficient, after dividing T1-2N0 breast cancer cases into different groups (score, 0–4). All statistical analyses were performed by IBM SPSS version 19.0, Chicago, IL. Any difference was considered to be statistically significant if P was <.05. […]

Pipeline specifications

Software tools Cutoff Finder, SPSS
Application Miscellaneous
Organisms Homo sapiens
Diseases Breast Neoplasms, Neoplasms