Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 10
Release date: Feb 10 2010
Last update date: Jul 31 2017
Access: Public
Diseases: Deficiency Diseases, Diabetes Mellitus, Type 1, Diabetic Neuropathies, Immune System Diseases, Lupus Erythematosus, Systemic, Rat-Bite Fever
Chemicals: Poly I-C, Tyrosine
Dataset link Gene expression profiling of pancreatic islets in BioBreeding rats

Experimental Protocol


In this study, using islet gene expression profiling, direct serum-level measurement, quantitative real-time PCR and targeted histological follow-up, we investigate pancreatic islet gene expression in BB rat at 5 weeks (+/-5 days) which is prior to insulitis in DRlyp/lyp rats. We compare DR+/+, JB++ & JBlyp/lyp islet activity to that of F344 and F344lyp/lyp rats to investigate any potential for reduction in capability to deal with oxidative stress in BB rats compared to non-BB and whether any differences in that capability map to known Iddm regions.

Repositories


GEO

GSE20214

ArrayExpress

E-GEOD-20214

BioProject

PRJNA125729

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Contact


Martin Hessner
Parthav Jailwala
Parthav A Jailwala