|Application:||aCGH data analysis|
|Number of samples:||54|
|Release date:||Sep 29 2009|
|Last update date:||Mar 21 2012|
|Diseases:||Neoplasms, Prostatic Neoplasms|
|Dataset link||Comparative analyses of chromosome alterations in metastases in castration-resistant prostate cancer patients|
The aim of this study was to characterize the genomic changes identified in a set of matched castrate-resistant primary and metastatic prostate cancers. Tumor cells were isolated by laser-capture microdissection from 14 patients, a total of 54 tumor samples. LCM capture samples were isolated from multiple metastastases from all but one patient from whom a single metastasis was available. Primary prostate tumor samples were collected from 12 patients. DNA was amplified by either ligation-mediated PCR (LMP) or WGA (Sigma-Aldrich, St. Louis, MO, USA). Reference DNA was isolated from peripheral blood from a single female individual.
Barbara J. Trask