Dataset features

Specifications


Application: aCGH data analysis
Number of samples: 54
Release date: Sep 29 2009
Last update date: Mar 21 2012
Access: Public
Diseases: Neoplasms, Prostatic Neoplasms
Chemicals: Androgens
Dataset link Comparative analyses of chromosome alterations in metastases in castration-resistant prostate cancer patients

Experimental Protocol


The aim of this study was to characterize the genomic changes identified in a set of matched castrate-resistant primary and metastatic prostate cancers. Tumor cells were isolated by laser-capture microdissection from 14 patients, a total of 54 tumor samples. LCM capture samples were isolated from multiple metastastases from all but one patient from whom a single metastasis was available. Primary prostate tumor samples were collected from 12 patients. DNA was amplified by either ligation-mediated PCR (LMP) or WGA (Sigma-Aldrich, St. Louis, MO, USA). Reference DNA was isolated from peripheral blood from a single female individual.

Repositories


GEO

GSE18259

ArrayExpress

E-GEOD-18259

BioProject

PRJNA119605

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Contact


Barbara Trask
Barbara J. Trask