Computational protocol: CO2BOLD assessment of moyamoya syndrome: Validation with single photon emission computed tomography and positron emission tomography imaging

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Protocol publication

[…] The CO2BOLD data were processed with the free FSL software (FMRIB Software Library, version 5.0.2.1; www.fmrib.ox.ac.uk/fsl). The essential processing steps include motion correction, spatial smoothing (10 mm filter size) and masking of non-brain voxels using brain extraction tool (BET, part of FSL). We then calculated parametric maps of the SURROGATE CVT response using an adapted ON-OFF regressor, which was convolved with a square basic shape corresponding to the ON-OFF CO2 inhalation. This schematic curvature was modified with a Gaussian convolution where the sigma factor was change. We calculated the maps with different models of sigma curvature to take into account delayed vascular response due to the proximal vascular stenosis. The delay was varied as 30, 45, 60, 75, 90 and 120 s to model variable speed of the CO2 induced BOLD response (Figure ). Both readers had all 6 maps available for the comparison between BOLD and PET/SPECT and reported that they preferentially used the 90 and 120 maps because the other maps were less informative. […]

Pipeline specifications

Software tools FSL, BET
Application Magnetic resonance imaging
Organisms Homo sapiens
Diseases Moyamoya Disease