|Number of samples:||11|
|Release date:||Jun 24 2015|
|Last update date:||Oct 18 2018|
|Diseases:||Brain Neoplasms, Glioblastoma, Glioma, Neoplasms|
|Dataset link||Identification of Global DNA Methylation Signatures in Glioblastoma-Derived Cancer Stem Cells|
The reduced representation bisulfite sequencing (RRBS) approach (Meissner et al., 2008) was used to generate genome-wide single-base resolution CpG methylation profiles of three primary GBMs (1063T, 1133T, and 1142T) and three GSC lines (1063S, 1133S, 1142S) derived from these primary GBM tumors. The NSC line and the normal brain (NB) tissue sample were used as controls for comparison purposes. In addition, we analyzed three GBM xenograft tumor tissue samples (Mayo22, Mayo39, Mayo59) developed by Dr. Jann N. Sarkaria of Mayo Clinic.