Computational protocol: Preterm Infant Feeding: A Mechanistic Comparison between a Vacuum Triggered Novel Teat and Breastfeeding

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Protocol publication

[…] Data analysis was run in R v3.0.3 for Mac OS X (Apple Inc., Cupertino, CA, USA), with additional packages nlme and lattice. Unless otherwise specified, summary statistics are presented as mean ± SD (range), while model parameters are presented as estimate (95% confidence interval (95% CI)). Model parameters are not presented for transformed data. Summary variables presented in were compared using either paired t-tests or paired Wilcoxon signed rank tests. Comparison of infants included in this study with those omitted used either independent samples t-tests or Fisher’s Exact test. All other analyses used linear mixed effects models to investigate differences by feed type, and simultaneous linear regression to investigate individual patterns, using the same fixed effects as the final mixed effects model. Model fit was assessed with residual plots. Where more than one random effects grouping was considered, models were compared using likelihood ratio tests. Multiple comparisons used Tukey’s all pair comparisons.Intra-oral vacuum data consisted of 1641 suck burst and 1607 pause records. Single sucks (102 breast, 193 NT) were omitted from vacuum analyses (other than mean pressure) as these measures cannot be made on single sucks. Five records (three breast, two NT) with a sucking rate ≥ 200 sucks/min were omitted as this indicates measurement artifacts. Missing data included tongue movement for two NT feeds; nipple diameters at 15 mm in 37 records, as insufficient nipple was drawn into the mouth to make the measurement and milk intakes for four feeds in three infants. […]

Pipeline specifications

Software tools nlme, lme4
Application Mathematical modeling
Organisms Homo sapiens