Computational protocol: Age-Related Changes in BOLD Activation Pattern in Phonemic Fluency Paradigm: An Investigation of Activation, Functional Connectivity and Psychophysiological Interactions

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Protocol publication

[…] AFNI software package (; Cox, ) was used for reconstruction, preprocessing and analysis of the MR images. Preprocessing steps for task fMRI included the removal of the first three volumes, motion correction, slice-timing correction, 6-mm full width at half maximum (FWHM) Gaussian smoothing, and percent signal change normalization of the BOLD signal. Data from subjects exceeding 2-mm motion in any direction were discarded from analysis. Functional and anatomical images were then aligned and transformed to Talairach coordinate system (Talairach and Tournoux, ). The subsequent preprocessed functional images underwent regression analysis with the verbal fluency task onset time-file serving as a regression model. The six parameters of rigid motion also were used as regressors of no-interest. To account for the difference in brain volume of the participants, and to address the concern of more interpolation in the older populations during normalization to template space, measures of intra-cortical brain volume, extracted using FSL's fast program [Functional Magnetic Resonance Imaging of the Brain (FMRIB) Software Library (FSL)], were used as covariates in the analysis. […]

Pipeline specifications

Software tools AFNI, FSL
Application Functional magnetic resonance imaging