|Application:||DNA methylation array analysis|
|Number of samples:||51|
|Release date:||Dec 31 2012|
|Last update date:||Jan 2 2015|
|Diseases:||Ovarian Diseases, Tumor Lysis Syndrome, Neoplasms, Second Primary, Cystadenoma, Serous|
|Dataset link||The DNA methylomes of serous borderline tumours reveal subgroups with malignant-like or benign-like profiles|
Array-based methylation profiling was performed using the Infinium HumanMethylation27 BeadChip in 12 low grade serous carcinoma, 19 serous borderline tumours and 16 benign serous tumours. The reproducibility of the Infinium HumanMethylation27 BeadChips was evaluated using four biological replicates of the high grade serous ovarian cancer cell line PEO1. Differential methylation cutoff was estimated from four biological replicates by bootstrap resampling and set at Δβ ≥ 0.25 corresponding to a FDR ≤ 0.09.