|Application:||ChIP-seq analysis, RNA-seq analysis|
|Number of samples:||42|
|Release date:||Nov 24 2012|
|Last update date:||Oct 10 2018|
|Dataset link||STATs Shape the Active Enhancer Landscape of T Cell Populations|
Active enhancer elements were defined as p300-high/H3K4me1-high. Using ChIP-seq, we mapped active enhancer landscapes of two CD4+ T helper cells, Th1 and Th2. To investigate the effect of STAT proteins on this landscape, we profiled active enhancers in the absence of STATs. Overall, STATs deficiency had a major impact on recruitment of p300. In addition, ectopic expression of master regulators T-bet and GATA3 in STAT-deficient cells failed to recover most active enhancers.