Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 32
Release date: Mar 7 2014
Last update date: Jan 9 2018
Access: Public
Diseases: Multiple Sclerosis
Dataset link Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 2)

Experimental Protocol


Patients with multiple sclerosis (MS) display variations in response to natalizumab treatment. PBMCs were collected from 8 high responders (HR) and 8 low responders (LR) to natalizumab treatment. CD4+ T cells were cultured for 48h. Cells were activated with anti-CD3 and anti-CD28 mAbs (0.5 µg/mL), either with natalizumab (25 µg/mL BiogenIdec) or without additional stimulus. Gene expression analysis was performed using SurePrint G3 Human Gene Expression 8X60K microarrays.

Repositories


GEO

GSE44964

ArrayExpress

E-GEOD-44964

BioProject

PRJNA192695

Download


Contact


Hui Wang