Computational protocol: Testing chemotherapy efficacy in HER2 negative breast cancer using patient-derived spheroids

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Protocol publication

[…] Data comparison across cell lines and patients was done using the Kruskal–Wallis test and subsequent post hoc analysis; p-values were adjusted for multiple testing. Two-group comparisons were done using the Mann–Whitney U test. Bivariate correlation was done using the Pearson correlation procedure. Results were considered significant if the p value was lower than 0.05. All statistical analysis was done using IBM SPSS Statistics Version 22. The treatment efficacy heatmap was generated using the program R version 3.1.2, module gplots heatmap2. […]

Pipeline specifications

Software tools SPSS, gplots
Application Miscellaneous
Chemicals Adenosine Triphosphate, Fluorouracil, Anthracyclines, Taxoids