|Application:||Gene expression microarray analysis|
|Number of samples:||6|
|Release date:||Mar 23 2012|
|Last update date:||Mar 6 2018|
|Diseases:||Fatty Liver, Chronobiology Disorders|
|Dataset link||Expression data from hepatocyte specific Klf6 knockout mice vs. control on high fat diet|
Three mice with a hepatocyte-specific knockdown of KLF6 (DeltaHepKlf6) on high fat diet and 3 littermate controls on the same diet were sacrificed after 8 weeks of diet. Liver tissue was preserved in RNAlater® (Ambion, Austin, TX). RNA was isolated from liver tissue and homogenized in TRIzol® reagent (Invitrogen, Carlsbad, CA). In order to identify potential KLF6 targets that contributed to changes in glucose- and lipid-metabolism, we performed an Affymetrix Exon1 S.T. Genearray® (Affymetrix, Santa Clara, CA).