|Application:||Gene expression microarray analysis|
|Number of samples:||72|
|Release date:||Jan 20 2010|
|Last update date:||Jan 18 2013|
|Dataset link||Expression profiles associated with BRCA1 and BRCA2 mutation status in familial breast cancer patients|
Total RNA was isolated from 27 lymphoblastoid cell-lines (LCLs) derived from affected women in high-risk breast cancer families (nine BRCA1, nine BRCA2, and nine non-BRCA1/2 women) and nine LCLs from healthy women. LCLs from each of the BRCA1, BRCA2 and BRCAX patient groups, and from healthy controls, were irradiated at 10 Gy using a calibrated Cesium-137 source or treated with MMC at two different doses (0.4 µM or 1.2 µM). Cells were harvested prior to IR or MMC treatment (T0), at 1 h after IR exposure, and at 1 and 2 h after exposure for MMC.
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