Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 72
Release date: Jan 20 2010
Last update date: Jan 18 2013
Access: Public
Diseases: Breast Neoplasms
Dataset link Expression profiles associated with BRCA1 and BRCA2 mutation status in familial breast cancer patients

Experimental Protocol


Total RNA was isolated from 27 lymphoblastoid cell-lines (LCLs) derived from affected women in high-risk breast cancer families (nine BRCA1, nine BRCA2, and nine non-BRCA1/2 women) and nine LCLs from healthy women. LCLs from each of the BRCA1, BRCA2 and BRCAX patient groups, and from healthy controls, were irradiated at 10 Gy using a calibrated Cesium-137 source or treated with MMC at two different doses (0.4 µM or 1.2 µM). Cells were harvested prior to IR or MMC treatment (T0), at 1 h after IR exposure, and at 1 and 2 h after exposure for MMC.

Repositories


GEO

GSE17764

BioProject

PRJNA118311

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Contact


Logan Walker

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