Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 617
Release date: Jul 23 2015
Last update date: Nov 8 2016
Access: Public
Diseases: Huntington Disease, Metabolic Diseases, Myositis, Parkinson Disease, Respiratory Tract Infections, Leukemia, Myeloid, Acute
Chemicals: Cholesterol, Simvastatin
Dataset link The effect of statins on blood gene expression in COPD

Experimental Protocol


Study subjects were a subset of those with COPD from the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study (Vestbo et al.), funded by GlaxoSmithKline (GSK Study No. SCO104960, NCT00292552). ECLIPSE is a non-interventional, observational, multicentre, three-year study in people with COPD. Blood was collected in PAXGene tubes and frozen at -80oC. In this work we have looked at the effect of statins on gene expression in 620 subjects of whom 168 were statin users. ECLIPSE study was described in: Vestbo J, Anderson W, Coxson HO, et al.: Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE). Eur Respir J. 2008;31(4):869-73

Repositories


GEO

GSE71220

ArrayExpress

E-GEOD-71220

BioProject

PRJNA290626

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Contact


Bruce McManus
Bruce Maxwell McManus

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