Computational protocol: Is detection of adverse events affected by record review methodology? an evaluation of the “Harvard Medical Practice Study” method and the “Global Trigger Tool”

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Protocol publication

[…] Categorical data are summarised using frequency counts and proportions (percent). Both the number of AEs per record and the number of records with at least one AE are presented. The calculation of 95% confidence interval for a proportion is based on exact methods according to Clopper-Pearson. Continuous data are presented as median and range/inter-quartile range. The inter-rater reliability was calculated using binary data. The Spearman rank order correlation coefficient (rs) was used to investigate “learning curves”. P<0.05 was considered statistically significant. Statistical programs used to collate the results were Excel and Statistica 9.0. […]

Pipeline specifications

Software tools SAMtools, Statistica
Diseases Deafness