Computational protocol: Implementing higher oxygen saturation targets reduced the impact of poor weight gain as a predictor for retinopathy of prematurity

Similar protocols

Protocol publication

[…] We analysed the WINROP predicted outcome and frequency of ROP treatment in infants with GAs of less than 31 weeks who had undergone at least one screening examination or treatment for ROP at the Queen Silvia Children's Hospital in Gothenburg. Infants were analysed from two time periods, before and after a change in oxygen saturation targets, from 88–92% in 2011–2012 to 91–95% in 2015–2016. Infants born during the first period had participated in a previous study . Data on GA, birthweight, gender and neonatal morbidities, such as bronchopulmonary dysplasia, necrotising enterocolitis and intraventricular haemorrhage were collected from hospital records. Bronchopulmonary dysplasia was defined as the need for continuous supplemental oxygen at 36 weeks of postmenstrual age (PMA), necrotising enterocolitis was defined as stage 2b or more, all grades of intraventricular haemorrhage were included, and sepsis was defined as a positive blood culture. Infants were included if they had survived complete ROP screening and reached approximately 40 weeks of PMA. We retrospectively collected weekly postnatal body weights, from birth to 34 weeks PMA. An online WINROP analysis requires accurate GA, birthweight and weekly weights, and infants were excluded when their weight measurements were incomplete and when their weight gain was considered to have any nonphysiological component, such as hydrocephalus. WINROP was developed for GAs of 23–32 weeks and that is why we excluded infants born at 22 weeks. [...] All statistical analyses were carried out with IBM SPSS Statistics, version 24 (IBM Corp, New York, USA). The negative predictive values (NPVs) and positive predictive values (PPVs) were calculated as well as the sensitivity, specificity and 95% confidence intervals. The Mann–Whitney U‐test, chi‐square test and Fisher's exact test were used to explore differences between variables.The research ethics committee of the University of Gothenburg approved the study protocol. […]

Pipeline specifications

Software tools WINROP, SPSS
Applications Miscellaneous, Medical phenotype analysis
Organisms Homo sapiens
Chemicals Oxygen