Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 12
Release date: Aug 22 2010
Last update date: Oct 29 2018
Access: Public
Diseases: Fibromyalgia, Scleroderma, Systemic
Dataset link Expression data from untreated and rottlerin-treated normal and systemic sclerosis-derived human fibroblasts

Experimental Protocol


Early passage normal and SSc human dermal fibroblasts were incubated with rottlerin (50 µg/mL) for 24 hours, followed by RNA extraction of treated and untreated samples and hybridization on Affymetrix microarrays. Early passage fibroblasts derived from normal and SSc dermal biopsies were utilized in this study to ensure that phenotypes remained as close as possible to original biopsy tissue. SSc patient sample biopsies were isolated from leading edge of forearm lesion; normal biopsies were obtained from forearm dermis.

Repositories


GEO

GSE23741

BioProject

PRJNA130767

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Contact


Peter Wermuth