Computational protocol: DOT1L promotes angiogenesis through cooperative regulation of VEGFR2 with ETS-1

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Protocol publication

[…] The H3K79me2 ChIP-seq data in HUVECs was from the ENCODE project (Broad/MGH ENCODE group; GSM1003555) []. H3K79me2 ChIP-seq peaks was called by CEAS (Cis-regulation element annotation system) to obtain the genomic annotation of H3K79me2 profile []. ChIP-seq profiling of H3K79me2 and H3K27ac in HUVECs over a 5-kb window around TSSs of all RefSeq genes was performed by seqMINER []. The H3K79me2 ChIP-seq enriched regions on tested genes were displayed on the IGV Browser (http://www.broadinstitute.org/igv). […]

Pipeline specifications

Software tools CEAS, seqMINER, IGV
Application ChIP-seq analysis
Organisms Homo sapiens