Computational protocol: Mentalizing the body: spatial and social cognition in anosognosia for hemiplegia

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Protocol publication

[…] Routinely acquired clinical scans (CT and/or MRI) obtained on admission were collected for 29 patients (clinical dataset of one patient with hemiplegia was unavailable). Lesions were reconstructed onto axial slices of a standard template in MRIcron ( ). A binary lesion mask was created for all patients. A trained researcher (S.F.), blinded to the clinical information, groupings and study hypotheses, reviewed the reconstructions for accuracy and anatomical validity. Lesion volume was extracted using FSL5 (FMRIB Software Library, http://fsl.fmrib.ox.ac.uk/fsl/ ). An independent t -test was used to assess mean differences between the clinical groups (AHP versus Hemiplegia). Group-level percentage lesion overlay maps for both groups and a subtraction map between them were computed in MRIcron. In addition, the binarized lesion masks were entered into a VLSM pipeline ( ) using the NPM program implemented in MRIcron (non-parametric mapping; http://www.cabiatl.com/mricro/npm/ ; ). Separate VLSM analyses (including all patients, irrespective of diagnostic classification) were run for the following dependent variables (all scores were continuous): (i) inverted Feinberg awareness scores; (ii) third person perspective taking scores in the visuospatial tasks; and (iii) third person perspective taking in ToM stories. For these behavioural measures, a lower score corresponded to lower awareness and lower perspective-taking ability in both the visuospatial perspective taking and ToM tasks. A VLSM Brunner-Menzel analysis with voxel-based permutation (1000) was conducted ( ; ). Only voxels where at least 10% of patients had damage were included in the analysis to avoid lowering statistical power by including infrequently damaged voxels whilst increasing the number of computed comparisons. Results were then projected onto a high-resolution template ( ) in standard space. Anatomical locations were cross-referenced using the Juelich histological atlas ( ) implemented within FSL. […]

Pipeline specifications

Software tools MRIcron, FSL
Application Magnetic resonance imaging
Organisms Homo sapiens
Diseases Brain Diseases, Central Nervous System Diseases, Stroke