Computational protocol: Mentalizing the body: spatial and social cognition in anosognosia for hemiplegia

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Protocol publication

[…] Routinely acquired clinical scans (CT and/or MRI) obtained on admission were collected for 29 patients (clinical dataset of one patient with hemiplegia was unavailable). Lesions were reconstructed onto axial slices of a standard template in MRIcron ( ). A binary lesion mask was created for all patients. A trained researcher (S.F.), blinded to the clinical information, groupings and study hypotheses, reviewed the reconstructions for accuracy and anatomical validity. Lesion volume was extracted using FSL5 (FMRIB Software Library, ). An independent t -test was used to assess mean differences between the clinical groups (AHP versus Hemiplegia). Group-level percentage lesion overlay maps for both groups and a subtraction map between them were computed in MRIcron. In addition, the binarized lesion masks were entered into a VLSM pipeline ( ) using the NPM program implemented in MRIcron (non-parametric mapping; ; ). Separate VLSM analyses (including all patients, irrespective of diagnostic classification) were run for the following dependent variables (all scores were continuous): (i) inverted Feinberg awareness scores; (ii) third person perspective taking scores in the visuospatial tasks; and (iii) third person perspective taking in ToM stories. For these behavioural measures, a lower score corresponded to lower awareness and lower perspective-taking ability in both the visuospatial perspective taking and ToM tasks. A VLSM Brunner-Menzel analysis with voxel-based permutation (1000) was conducted ( ; ). Only voxels where at least 10% of patients had damage were included in the analysis to avoid lowering statistical power by including infrequently damaged voxels whilst increasing the number of computed comparisons. Results were then projected onto a high-resolution template ( ) in standard space. Anatomical locations were cross-referenced using the Juelich histological atlas ( ) implemented within FSL. […]

Pipeline specifications

Software tools MRIcron, FSL
Application Magnetic resonance imaging
Organisms Homo sapiens
Diseases Brain Diseases, Central Nervous System Diseases, Stroke