Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 32
Release date: Dec 25 2016
Last update date: May 4 2018
Access: Public
Diseases: Lymphoma, B-Cell, Marginal Zone
Dataset link Expression data from intestinal mucosa of Zucker rats

Experimental Protocol


Forty-eight Zucker-Leprfa/fa and 16 Zucker-lean+/fa male rats weighing 168-180 g were used. After 5 days of adaptation, 8 Zucker-lean+/fa (lean reference) and 8 Zucker-Leprfa/fa rats (obese reference) were euthanized as a reference. The remaining 40 Zucker-Leprfa/fa rats were then randomly assigned to receive 10^10 CFUs of one of the three probiotic strains (probiotic strains groups), or a placebo (obese placebo) by oral administration each day for 30 days. An additional group of 8 Zucker-lean+/fa rats (control placebo) received placebo. Samples of intestinal mucosa were taken and RNA isolated to carry out a differential gene expression study. with an Affymetrix microarray (Rat Gene 1.1 ST Array Plate).

Repositories


GEO

GSE73848

BioProject

PRJNA298220

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Contact


Julio Plaza Diaz

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