Computational protocol: Association Study of Fibroblast Growth Factor 2 and Fibroblast Growth Factor Receptors Gene Polymorphism in Korean Ossification of the Posterior Longitudinal Ligament Patients

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Protocol publication

[…] Statistical analyses were performed using the SPSS software (version 17.0, Chicago, IL, USA).The chi-squared (χ2) test was used to evaluate Hardy-Weinberg equilibrium (HWE) between each genotype and each individual. Single SNP analyses were performed using the SNPAnalyzer and SNPStats software (http://bioinfo.iconcologia.net/index.php). SNP effects were analyzed using codominant, dominant, and recessive models. Logistic regression models were calculated for odds ratios (OR), 95% confidence intervals (CIs), and corresponding p values, while controlling for gender as a covariable. Significance was set at p<0.05 for all statistical tests.To evaluate the presence of linkage disequilibrium (LD) and blocks of haplotypes between polymorphisms within the FGF2, FGFR1, and FGFR2 genes, LD and haplotypes were analyzed using the Haploview software, version 4.1. […]

Pipeline specifications

Software tools snpStats, Haploview
Application GWAS
Organisms Homo sapiens
Diseases Hyperostosis, Diffuse Idiopathic Skeletal