|Application:||Gene expression microarray analysis|
|Number of samples:||360|
|Release date:||Mar 18 2010|
|Last update date:||Aug 10 2018|
|Diseases:||Bacterial Infections, Pharyngitis, Pneumococcal Infections, Mucositis|
|Dataset link||Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus|
Longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus Briefly, animals were GAS-culture negative and had negligible antistreptolysin O titers, indicating no recent history of GAS exposure. Twenty animals were subjected to a mock-inoculation protocol (PBS only) for 5 weeks, rested for 4 weeks, and inoculated in the upper respiratory tract with 107 CFUsMGAS5005. Blood, saliva, and throat swabs were collected on days 0, 1, 2, 4, 7, 9, 16, 23, 32, 45, 58, 72, and 86. Only the first nine time-points were studied because specimens collected during days 0 to 32 had matching comparator specimens from the mock-infection protocol. Thirty-two clinical and laboratory parameters were measured by the same veterinarian during mock and infection periods. Array data was only for the tonsil swabs, while blood and saliva used for other tests.