Computational protocol: Potential Biomarkers of the Earliest Clinical Stages of Parkinson's Disease

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Protocol publication

[…] The sequences of the primers and probes were designed using Beacon designer 7.0 software (Premier Biosoft International, Palo Alto, CA, USA).Relative levels of the transcripts in the test groups were calculated as R = 2−ΔΔCp []. The levels of the transcripts studied in the group of healthy controls were set as 1. Data were analyzed using the nonparametric Mann-Whitney U test with “Statistica for Windows 8.0” (StatSoft, Inc. (2007)) and MS Excel 2010 (Microsoft). ROC curves and PCR efficiency and specificity were obtained by using and Real Statistics Resource Pack of MS Excel 2013 (Microsoft). […]

Pipeline specifications

Software tools Beacon Designer, Statistica
Applications Miscellaneous, qPCR
Organisms Homo sapiens
Diseases Parkinson Disease, Neurodegenerative Diseases