|Application:||Gene expression microarray analysis|
|Number of samples:||1|
|Release date:||Jul 18 2005|
|Last update date:||Mar 16 2012|
|Diseases:||Diabetes Mellitus, Neoplasms|
|Dataset link||Gestational Diabetes Induces Placental Genes for Chronic Stress and Inflammatory Pathways|
To characterize gene targets that determine altered placental functions, the global pattern of gene expression was analyzed in placenta from matched control subjects and GDM pregnancies. Of 22,823 gene sequences surveyed, 8,627 ± 172 were present in control subjects and 9,378 ± 165 in GDM, representing placental transcriptome. The consecutive screening filters that we applied allowed us to narrow these numbers to 2,682 genes eligible for analysis. The average fold change value was then calculated for all pairwise comparisons, resulting in the final selection of 435 genes significantly modified in GDM.
Sylvie Hauguel-de Mouzon