|Application:||Gene expression microarray analysis|
|Number of samples:||15|
|Release date:||Jun 14 2017|
|Last update date:||Nov 9 2017|
|Diseases:||Leukemia, Myeloid, Acute|
|Dataset link||Effect on bone marrow mesenchymal stromal cells of mouse models of acute myeloid leukemia of different genotypes|
We established syngeneic AML, produced by different known AML fusion oncogenes, in C57BL/6 mice and isolated their BM-MSC. Gene expression profiling was used to compare AML-exposed MSC to those of control mice. BM-derived normal MSC were also cultured in vitro with tp53 WT and tp53-/- AML cells of the same genotype (MLL/ENL+FLT3-ITD).