Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 32
Release date: Dec 9 2015
Last update date: Jul 19 2017
Access: Public
Diseases: Ataxia Telangiectasia, Deficiency Diseases, Lymphoma, Neoplasms, Leukemia, B-Cell, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse
Dataset link ATM-deficient B cell lymphomas

Experimental Protocol


We performed gene expression profiling on nine ATMKO.CD3epsilonKO lymphoma cell lines (n=12, 3 technical repeats). We analyzed gene expression of anti-IgM stimulated primary B cells from both ATMKO.CD3epsilonKO (n=7, 5 technical repeats) and ATMWT.CD3epsilonKO mice (n=2), and GC B cells isolated from SRBC-immunized ATMWT mice (n=3, 1 biological repeat and 2 technical repeats). We analyzed gene expression following treatment of two ATMKO.CD3epsilonKO lymphoma cell lines with the BTK inhibitor, PCI-32765, at time points (1, 3, 6, and 24 hours) as compared to time points with vehicle (DMSO) (n=8).

Repositories


GEO

GSE68505

ArrayExpress

E-GEOD-68505

BioProject

PRJNA282948

Download


Contact


Louis Staudt
Louis M. Staudt