|Dataset type:||Expression profiling by array|
|Number of samples:||6|
|Release date:||Jan 2 2019|
|Last update date:||Jan 3 2019|
|Dataset link||CCN2-MAPK-Id-1 Loop Feedback Amplification is involved in Maintaining Stemness in Oxaliplatin-resistant Hepatocellular Carcinoma|
In the present study, we determined that increased Id-1 and CCN2 expression were closely correlated with oxaliplatin resistance in HCC, verified that malignancy and poor prognosis were associated with Id-1 in human HCC, and explored the negative roles of Id-1 and the regulatory mechanisms of CCN2 in HCC. Finally, we demonstrated enhanced stemness and the upregulation of Id-1 in HCC after oxaliplatin treatment, which could be reversed by CCN2-MAPK-Id-1 signaling loop inhibition.