Dataset features

Specifications


Dataset type: Expression profiling by array
Number of samples: 6
Release date: Jan 2 2019
Last update date: Jan 3 2019
Access: Public
Dataset link CCN2-MAPK-Id-1 Loop Feedback Amplification is involved in Maintaining Stemness in Oxaliplatin-resistant Hepatocellular Carcinoma

Experimental Protocol


In the present study, we determined that increased Id-1 and CCN2 expression were closely correlated with oxaliplatin resistance in HCC, verified that malignancy and poor prognosis were associated with Id-1 in human HCC, and explored the negative roles of Id-1 and the regulatory mechanisms of CCN2 in HCC. Finally, we demonstrated enhanced stemness and the upregulation of Id-1 in HCC after oxaliplatin treatment, which could be reversed by CCN2-MAPK-Id-1 signaling loop inhibition.

Repositories


GEO

GSE124529

BioProject

PRJNA512377

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Contact


Xia Liao