Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 16
Release date: Apr 9 2018
Last update date: Apr 11 2018
Access: Public
Diseases: Brain Concussion, Cockayne Syndrome
Dataset link Generation of splice switching oligonucleotides targeting the Cockayne syndrome group B gene product in order to change the diseased cell state

Experimental Protocol


In this study, we investigated whether it was possible to get Cockayne syndrome (CS) cells to mimic UV sensitive syndrome (UVSS) cell by using splice switching oligonucleotides (SSOs). Thus, we needed to assess whether the states of SSO-transfected cells were close to CS or UVSS cells. One of the way to assess that, a microarray analysis was performed to define the differences in gene expression states between CS and UVSS. Gene expression states of each patient cell lines were compared, WI-28 VA13 sub 2 RA (normal) vs UVS1KO (UVSS), CS1AN (AN) vs UVS1KO (UVSS) and CS1BE (BE) vs UVS1KO (UVSS) (n=4).

Repositories


GEO

GSE111989

BioProject

PRJNA438889

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Contact


Yooksil SIN