|Application:||Gene expression microarray analysis|
|Number of samples:||16|
|Release date:||Apr 9 2018|
|Last update date:||Apr 11 2018|
|Diseases:||Brain Concussion, Cockayne Syndrome|
|Dataset link||Generation of splice switching oligonucleotides targeting the Cockayne syndrome group B gene product in order to change the diseased cell state|
In this study, we investigated whether it was possible to get Cockayne syndrome (CS) cells to mimic UV sensitive syndrome (UVSS) cell by using splice switching oligonucleotides (SSOs). Thus, we needed to assess whether the states of SSO-transfected cells were close to CS or UVSS cells. One of the way to assess that, a microarray analysis was performed to define the differences in gene expression states between CS and UVSS. Gene expression states of each patient cell lines were compared, WI-28 VA13 sub 2 RA (normal) vs UVS1KO (UVSS), CS1AN (AN) vs UVS1KO (UVSS) and CS1BE (BE) vs UVS1KO (UVSS) (n=4).