Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 6
Release date: May 12 2015
Last update date: Oct 11 2016
Access: Public
Chemicals: Benzo(a)pyrene, Dexamethasone, Phenobarbital
Dataset link Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells [PB]

Experimental Protocol


This experiment examined the whole genome transcriptional response of TK6 cells exposed to phenobarbital for 4 hours followed by recovery times of 4h and 20h in fresh media (8h and 24h time points, respectively) at 3 different concentrations, including a low (1 mM), a medium (3.2 mM), and a high (10 mM) concentration, in addition to a vehicle control (+S9). Each concentration and time point had 3 biological replicates, which were pooled for gene expression analysis. There were a total of 6 samples (12 arrays) included in the final analysis using a two-colour dye swap design.

Repositories


GEO

GSE68774

ArrayExpress

E-GEOD-68774

BioProject

PRJNA283791

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Contact


Julie Buick

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