Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 24
Release date: Sep 1 2015
Last update date: Jul 31 2017
Access: Public
Taxon: Mus musculus, Rattus norvegicus
Dataset link Transcriptomic Responses to Prion Disease in Rats

Experimental Protocol


We Adapted RML Mouse Scrapie into Rats and measured the resulting gene expression changes in brain as a result of disease progression. Rats were infected by intracranial inoculation with prion isolates obtained by adaptation of mouse RML scrapie prions into rats. Brain samples were collected from third and fourth passage infected rats and age-matched controls at specified timepoints and gene expression profiles obtained. For each time point, 3 diseased and control brain samples were profiled.

Repositories


GEO

GSE63930

ArrayExpress

E-GEOD-63930

BioProject

PRJNA269508

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