|Application:||Gene expression microarray analysis|
|Number of samples:||24|
|Release date:||Sep 1 2015|
|Last update date:||Jul 31 2017|
|Taxon:||Mus musculus, Rattus norvegicus|
|Dataset link||Transcriptomic Responses to Prion Disease in Rats|
We Adapted RML Mouse Scrapie into Rats and measured the resulting gene expression changes in brain as a result of disease progression. Rats were infected by intracranial inoculation with prion isolates obtained by adaptation of mouse RML scrapie prions into rats. Brain samples were collected from third and fourth passage infected rats and age-matched controls at specified timepoints and gene expression profiles obtained. For each time point, 3 diseased and control brain samples were profiled.
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