Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 18
Release date: Dec 19 2014
Last update date: Aug 6 2018
Access: Public
Diseases: Cardiovascular Diseases, Hepatitis
Chemicals: Cholesterol, Cholesterol Esters, Triglycerides
Dataset link The TMAO Generating Enzyme Flavin Monooxygenase 3 is a Central Regulator of Cholesterol Balance

Experimental Protocol


To identify potential regulators of macrophage reverse cholesterol transport (RCT), liver was isolated from two independent mouse models where the non-biliary RCT pathway known as transintestinal cholesterol excretion (TICE) was either chronically (NPC1L1-liver-transgenic mice) or acutely (ACAT2 antisense oligonucleotide treatment) stimulated. Total RNA was isolated and gene expression levels were profiled on the Affymetrix GeneAtlas MG-430 PM Array Strip (Affymetrix; Santa Clara, CA, USA)

Repositories


GEO

GSE64326

ArrayExpress

E-GEOD-64326

BioProject

PRJNA270757

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Contact


Jeff Chou