Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 36
Release date: Mar 16 2011
Last update date: Nov 9 2017
Access: Public
Diseases: Neoplasms, Glandular and Epithelial
Dataset link Age-dependent decline in lung regeneration with loss of clonogenicity and myofibroblastic differentiation of lung fibroblasts

Experimental Protocol


Microarray analyses of mRNA expression patterns were performed on lung tissue from 9 month versus 3 month mice, before and after PNX. First, gene expression was compared in whole lungs tissues of young (3 month) vs. middle age (9 month) animals obtained at surgery (left, control lung). Second, the global gene expression responses of 3 vs. 9 mo mice were compared after PNX (1, 3 and 7 days) in the right lung. For each animal in the surgical study, the left (excised) lung lobe was used as a control for the corresponding right lung at the end of the study. This design was intended to increase the statistical power for detecting differences in gene expression by comparing pre- and post-PNX lung tissue from the same biological pools (2 animals/pool, 3 pools per group).

Repositories


GEO

GSE27964

ArrayExpress

E-GEOD-27964

BioProject

PRJNA137755

Download


Contact


Julia Paxson
Julia A Paxson