Computational protocol: Interspecies Variation of In Vitro Stability and Metabolic Diversity of YZG-331, a Promising Sedative-Hypnotic Compound

Similar protocols

Protocol publication

[…] The pharmacokinetic parameters for YZG-331/M2 in plasma were determined by noncompartmental analysis using Phoenix WinNonlin 6.3 (Pharsight Corporation, Mountain View, CA, United States). Statistical analyses between the two groups were performed with a two-tailed Student’s t-test, while multi-comparisons were performed using one-way ANOVA. Values of p < 0.05 were considered to statistically significant. The contents of metabolites from LMs incubation were evaluated by principal component analysis (PCA) using SPSS software (; ). […]

Pipeline specifications

Software tools Phoenix WinNonlin, SPSS
Application Miscellaneous
Organisms Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
Chemicals Adenosine, Hydroxyl Radical